Respective implications of glutamate decarboxylase antibodies in stiff person syndrome and cerebellar ataxia
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چکیده
منابع مشابه
Respective implications of glutamate decarboxylase antibodies in stiff person syndrome and cerebellar ataxia
BACKGROUND To investigate whether Stiff-person syndrome (SPS) and cerebellar ataxia (CA) are associated with distinct GAD65-Ab epitope specificities and neuronal effects. METHODS Purified GAD65-Ab from neurological patients and monoclonal GAD65-Ab with distinct epitope specificities (b78 and b96.11) were administered in vivo to rat cerebellum. Effects of intra-cerebellar administration of GAD...
متن کاملAnti glutamate-decarboxylase antibodies: a liaison between localisation related epilepsy, stiff-person syndrome and type-1 diabetes mellitus.
We present two patients with partial epilepsy, type-1 diabetes and stiff person syndrome associated with high serum auto-antibody levels to glutamate-decarboxylase (anti-GAD). Both patients were or have suffered from additional autoimmune conditions. The presence of stiff person syndrome and elevated anti-GAD levels have to make clinicians look for additional autoimmune conditions including typ...
متن کاملAnesthetic implications in stiff-person syndrome.
Stiff-person syndrome (SPS) is a rare neurologic disease manifested by persistent muscle contractions causing marked rigidity in the affected individual . There are many case descriptions and clinical reviews in the neurologic literature, outlining a progression of knowledge from the early clinical description of SPS to advanced molecular biologic and immunologic studies implicating the gamma-a...
متن کاملAcute Cerebellar Ataxia Associated with Anti-glutamic Acid Decarboxylase Antibodies Mimicking Miller Fisher Syndrome
We herein report the case of a 53-year-old man with cerebellar ataxia with anti-glutamic acid decarboxylase antibody (GAD-Ab) who mimicked Miller Fisher syndrome (MFS). He developed ophthalmoplegia, diplopia, and gait ataxia for one week. The serum and cerebrospinal fluid GAD-Ab titers were greatly increased, and the GAD-Ab index suggesting intrathecal antibody synthesis was elevated, while GQ1...
متن کاملStiff eyes in stiff-person syndrome.
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ژورنال
عنوان ژورنال: Orphanet Journal of Rare Diseases
سال: 2011
ISSN: 1750-1172
DOI: 10.1186/1750-1172-6-3